Home Health News Super-potent human antibodies protect against COVID-19 in animal tests – Medical Xpress

Super-potent human antibodies protect against COVID-19 in animal tests – Medical Xpress

9 min read
21
7

A colorized scanning electron micrograph of the SARS-CoV-2 virus. Credit: NIAID

A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus that causes the disease, when tested in animals and human cell cultures.

The research, published today in Science, offers a paradigm of swift reaction to an emergent and deadly viral pandemic, and sets the stage for clinical trials and additional tests of the antibodies, which are now being produced as potential treatments and preventives for COVID-19.

“The discovery of these very represents an extremely rapid response to a totally new pathogen,” says study co-senior author Dennis Burton, Ph.D., the James and Jessie Minor Chair in Immunology in the Department of Immunology & Microbiology at Scripps Research.

In principle, injections of such antibodies could be given to patients in the early stage of COVID-19 to reduce the level of virus and protect against severe disease. The antibodies also may be used to provide temporary, vaccine-like protection against SARS-CoV-2 infection for healthcare workers, and others who respond poorly to traditional vaccines or are suspected of a recent exposure to the coronavirus.

The project was led by groups at Scripps Research; IAVI, a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges; and University of California San Diego School of Medicine.

“It has been a tremendous collaborative effort, and we’re now focused on making large quantities of these promising antibodies for clinical trials,” says co-lead author Thomas Rogers, MD, Ph.D., an adjunct assistant professor in the Department of Immunology & Microbiology at Scripps Research, and assistant professor of Medicine at UC San Diego.

An approach that’s worked for other deadly viruses

Developing a treatment or vaccine for severe COVID-19 is currently the world’s top public health priority. Globally, almost 8 million people have tested positive for SARS-CoV-2 infection, and more than 400,000 have died of severe COVID-19. The daily toll of new infections is still rising.

One approach to new viral threats is to identify, in the blood of recovering patients, antibodies that neutralize the virus’s ability to infect .

These antibodies can then be mass-produced, using biotech methods, as a treatment that blocks severe disease and as a vaccine-like preventive that circulates in the blood for several weeks to protect against infection. This approach already has been demonstrated successfully against Ebola virus and the pneumonia-causing respiratory syncytial virus, commonly known as RSV.

Potent patient antibodies block the virus

For the new project, Rogers and his UC San Diego colleagues took blood samples from patients who had recovered from mild-to-severe COVID-19. In parallel, scientists at Scripps Research and IAVI developed test cells that express ACE2, the receptor that SARS-CoV-2 uses to get into human cells. In a set of initial experiments, the team tested whether antibody-containing blood from the patients could bind to the virus and strongly block it from infecting the test cells.

The scientists were able to isolate more than 1,000 distinct antibody-producing immune cells, called B cells, each of which produced a distinct anti-SARS-CoV-2 antibody. The team obtained the antibody gene sequences from these B cells so that they could produce the antibodies in the laboratory. By screening these antibodies individually, the team identified several that, even in tiny quantities, could block the virus in test cells, and one that could also protect hamsters against heavy viral exposure.

All of this work—including the development of the cell and animal infection models, and studies to discover where the antibodies of interest bind the virus—was completed in less than seven weeks.

“We leveraged our institution’s decades of expertise in antibody isolation and quickly pivoted our focus to SARS-CoV-2 to identify these highly potent antibodies,” says study co-author Elise Landais, Ph.D., an IAVI principal scientist.

If further safety tests in animals and in people go well, then conceivably the antibodies could be used in clinical settings as early as next January, the researchers say.

“We intend to make them available to those who need them most, including people in low- and middle-income countries,” Landais says.

In the course of their attempts to isolate anti-SARS-CoV-2 antibodies from the COVID-19 patients, the researchers found one that can also neutralize SARS-CoV, the related coronavirus that caused the 2002-2004 outbreak of severe acute respiratory syndrome (SARS) in Asia.

“That discovery gives us hope that we will eventually find broadly neutralizing that provide at least partial protection against all or most SARS coronaviruses, which should be useful if another one jumps to humans,” Burton says.


Explore further

Am I immune to COVID-19 if I have antibodies?


More information:
Thomas F. Rogers et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science 15 Jun 2020, DOI: 10.1126/science.abc7520 , science.sciencemag.org/content … 6/15/science.abc7520

Citation:
Super-potent human antibodies protect against COVID-19 in animal tests (2020, June 15)
retrieved 15 June 2020
from https://medicalxpress.com/news/2020-06-super-potent-human-antibodies-covid-animal.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Let’s block ads! (Why?)


Source link

21 Comments

  1. ปั้มไลค์

    June 16, 2020 at 1:24 am

    Like!! Great article post.Really thank you! Really Cool.

    Reply

  2. I really like and appreciate your blog post.

    Reply

  3. These are actually great ideas in concerning blogging.

    Reply

  4. เบอร์มงคล

    June 16, 2020 at 1:28 am

    Good one! Interesting article over here. It’s pretty worth enough for me.

    Reply

  5. SMS

    June 16, 2020 at 1:30 am

    bookmarked!!, I like your blog!

    Reply

  6. know g

    June 20, 2020 at 6:58 am

    Definitely imagine that which you stated. Your favorite justification appeared to be on the web the simplest factor to take
    into accout of. I say to you, I definitely get annoyed while people consider worries that they just do not
    know about. You managed to hit the nail upon the highest
    and defined out the entire thing without having side effect , other people could take a
    signal. Will likely be again to get more. Thanks

    Reply

  7. my g

    June 21, 2020 at 3:27 am

    Heya i am for the first time here. I came across this
    board and I to find It truly helpful & it helped me out
    much. I’m hoping to provide one thing again and aid others such as you helped me.

    Reply

  8. g https://tinyurl.com/rsacwgxy

    June 22, 2020 at 12:09 am

    Hi! I know this is somewhat off topic but I was wondering if you knew where I could locate a captcha plugin for
    my comment form? I’m using the same blog platform as
    yours and I’m having problems finding one? Thanks a lot!

    Reply

  9. legride.com

    June 26, 2020 at 4:16 am

    This is my first time pay a quick visit at here and i am really happy to read everthing at single place.

    Reply

  10. tinyurl.com

    June 26, 2020 at 6:13 pm

    You are so cool! I do not think I’ve read anything like this before.
    So nice to find another person with original thoughts on this subject.
    Really.. thank you for starting this up. This site is something that’s needed on the
    internet, someone with a little originality!

    Reply

  11. hosting services

    July 17, 2020 at 9:41 pm

    Hi there, I enjoy reading all of your article. I like to write a little comment to support you.

    Reply

  12. web hosting service

    July 23, 2020 at 1:47 am

    Hi there, just became aware of your blog through Google, and
    found that it’s really informative. I’m gonna watch out for brussels.
    I’ll appreciate if you continue this in future.
    A lot of people will be benefited from your writing.
    Cheers!

    Reply

  13. best web hosting sites

    August 5, 2020 at 4:10 pm

    I am regular visitor, how are you everybody? This article posted at this site is really nice.

    Reply

  14. content hosting

    August 5, 2020 at 6:23 pm

    I do trust all the ideas you’ve offered to your post.
    They’re really convincing and can definitely work.
    Nonetheless, the posts are very short for beginners.
    Could you please extend them a little from next time?
    Thanks for the post.

    Reply

  15. best web hosting 2020

    August 7, 2020 at 6:11 am

    Great beat ! I wish to apprentice while you amend your site, how can i subscribe for a
    blog website? The account helped me a acceptable deal.
    I had been a little bit acquainted of this your broadcast offered bright clear concept

    Reply

  16. web hosting service

    August 7, 2020 at 7:28 am

    I’m gone to say to my little brother, that he should also pay a visit this webpage on regular basis to obtain updated from latest reports.

    Reply

  17. content hosting

    August 14, 2020 at 5:23 am

    Hello to every body, it’s my first pay a visit of this weblog;
    this web site contains remarkable and genuinely excellent information in support of visitors.

    Reply

  18. cheap flights

    August 24, 2020 at 4:53 am

    Hey! I just wanted to ask if you ever have any issues with hackers?
    My last blog (wordpress) was hacked and I ended up losing several
    weeks of hard work due to no backup. Do you have any methods to prevent hackers?

    Reply

  19. cheap flights

    August 27, 2020 at 5:27 am

    Hi it’s me, I am also visiting this website regularly, this web page is really
    nice and the viewers are truly sharing good thoughts.

    Reply

  20. web hosting providers

    September 5, 2020 at 7:39 am

    You’ve made some really good points there.

    I checked on the web for more info about the issue and found most people will go along
    with your views on this site.

    Reply

  21. Social Media Marketing

    September 12, 2020 at 4:13 pm

    I’m really impressed along with your writing talents as well as with the format on your blog. Is this a paid subject matter or did you customize it yourself? Either way keep up the excellent high quality writing, it is rare to see a nice weblog like this one today.

    Reply

Leave a Reply

Your email address will not be published. Required fields are marked *

Check Also

China’s Covid-19 vaccine diplomacy steals a march on US – Financial Times

China is promising preferential access to its Covid-19 vaccines to countries across Asia, …