Home Health News Alzheimer's blood test in your doctor's office closer to reality, studies say – CNN

Alzheimer's blood test in your doctor's office closer to reality, studies say – CNN

11 min read


In a study presented Tuesday at the conference and published in JAMA, a blood test to detect the tau protein, one of the hallmark signs of Alzheimer’s, was as accurate as a spinal tap or a positron emission tomography (PET) scan, which are the current gold standards of diagnosis while a person is living.
The test could also differentiate between
More research is required and such a test is likely still years away from being available, but researchers said the results are promising.
“This research represents an exciting step towards developing a blood test that could help identify Alzheimer’s disease by focusing on specific sub-types of tau, one of the key proteins that becomes abnormal as part of the Alzheimer’s disease changes in the brain,” said Clive Ballard, professor of age-related disease at the University of Exeter Medical School, in the UK, who was not involved in the study.
Flu and pneumonia shots may lower risk for Alzheimer's, studies findFlu and pneumonia shots may lower risk for Alzheimer's, studies find
“A reliable blood test for Alzheimer’s disease would be a huge boost for dementia research, allowing scientists to test treatments at a much earlier stage which in turn could lead to a breakthrough for those living with dementia,” said Dr. Rosa Sancho, head of research at Alzheimer’s Research UK, who was also not involved in the study.

Looking for a mutant protein

In a three-part study, researchers from the United States and Sweden measured an abnormal version of the tau protein called p-tau217 and found more of that modified tau in the blood of people with Alzheimer’s disease than in healthy participants.
How does tau get into blood? It appears to cross the blood-brain barrier.
“Tau protein is modified and clumps abnormally in the brains of people with Alzheimer’s disease and some frontotemporal dementias, and some of this tau protein leaks out of the brain into the blood,” said Tara Spires-Jones, the deputy director of the Centre for Discovery Brain Sciences at the University of Edinburgh, who was not involved in the study.
 21 ways to reduce your Alzheimer's risk, backed by research 21 ways to reduce your Alzheimer's risk, backed by research
The researchers report the blood test can distinguish Alzheimer’s disease from other types of dementia and Parkinson’s with a high degree of accuracy — 89% to 98%.
Additionally, measuring p-tau217 levels may also be able to detect brain changes 20 years before dementia symptoms occur.
“This test, once verified and confirmed, opens the possibility of early diagnosis of Alzheimer’s before the dementia stage, which is very important for clinical trials evaluating novel therapies that might stop or slow down the disease process,” the researchers, led by Dr. Oskar Hansson from Lund University in Sweden, wrote.
Another study, published Tuesday in the Journal of Experimental Medicine, also verified that p-tau217 was more closely related to amyloid buildup in the brain than other chemicals that have been investigated.
“These two papers add to increasing evidence that modified tau proteins in the blood can accurately reflect Alzheimer’s disease in processes occurring in the brain,” said Amanda Heslegrave, a senior research fellow at the UK Dementia Research Institute at University College London, who was not involved in the study.

In your doctor’s office

The formation of brain proteins, amyloid and tau, into clumps of amyloid plaques and tau tangles are defining physical features of Alzheimer’s disease, but they are hard to detect without expensive PET scans or invasive spinal taps, neither of which is routinely covered by insurance.
Doctors are left with verbal and written tests of memory and cognitive impairment, combined with interviews with patients’ family members and caregivers about their behavior. That approach makes it tough to accurately diagnosis Alzheimer’s as distinct from other types of cognitive impairment.
Age-proof your brain by keeping your heart healthy, study saysAge-proof your brain by keeping your heart healthy, study says
In addition, brain scans and spinal taps can only identify beta amyloid plaques, not the tau protein. A test for tau is important, experts say — beta amyloid alone isn’t enough to diagnose Alzheimer’s because some people with high levels don’t develop the neurological disease.
The new blood test is able to detect both amyloid plaques and tau tangles and is very specific to Alzheimer’s, experts said.
A third abstract presented at the Alzheimer’s conference found the test could differentiate between less common frontotemporal dementia, which affects younger people and leads to changes in behavior and personality rather than memory loss, and Alzheimer’s, illustrating the test’s diagnostic abilities. These include changes in personality, behavior and difficulties with language.
“These studies (and others) show that blood based tau is a marker of amyloid pathology. Very interesting and not what would have been predicted 5 years ago,” said John Hardy, the chair of Molecular Biology of Neurological Disease at University College London.
These advances mean a day may come in the next few years when your health care provider can do a blood test for Alzheimer’s while you are at the doctor’s office, experts say.
“It is very exciting, because we all know that blood tests are really important and they’re necessary as a first pass in the clinic, in your general practitioner’s office,” said Maria Carrillo, chief medical officer of the Alzheimer’s Association.
Belly fat in older women is linked to a 39% higher risk of dementia within 15 years, study saysBelly fat in older women is linked to a 39% higher risk of dementia within 15 years, study says
And unlike current detection methods, blood tests could more easily be scaled up to test many people at much lower cost.
Early detection and treatment before significant damage from Alzheimer’s disease occurs to the brain would be a game changer for individuals, experts said. The test could also help to identify the right people for clinical drug trials.
“We know that brain changes in Alzheimer’s disease can occur decades before symptoms start to show and the early stages of disease are likely to be the time when future drugs are most effective,” Sancho said.
Carrillo and other experts caution that while promising, the blood test still needs to be tested among asymptomatic people and larger populations.
“Now we need longer and larger studies to validate these results and find out if this test could accelerate our ability to develop new treatments for Alzheimer’s disease in the future.” said Fiona Carragher, director of policy and research at Alzheimer’s Society in the UK.
Ballard agrees: “Although this research looks extremely promising, further validation in people from more routine clinical settings are still needed, and a lot of work will be needed to achieve standardisation of the test across laboratories.
“So it could still be at least five years before we see an accurate blood biomarker test for dementia it in the clinic.”

Let’s block ads! (Why?)

Source link


  1. Sandi Mckellips

    May 10, 2021 at 7:28 pm

    Have you ever heard of second life (sl for short). It is basically a video game where you can do anything you want. SL is literally my second life (pun intended lol). If you want to see more you can see these Second Life websites and blogs


  2. Lael Mazzanti

    June 7, 2021 at 7:08 pm

    This was awesome! I would like you to clean up all this spam though


  3. Glynis Germann

    June 9, 2021 at 9:14 am

    This was great! I would like you to clean up all this spam though


  4. Anton Vanduyne

    June 13, 2021 at 11:10 pm

    I don’t know about you people but I love airplanes. I had a friend in highschool that loves airplanes, so here are some airplane related stuff I don’t know about you guys but I love airplanes. I had a friend in highschool that loved airplanes, so here are some airplane related stuff https://www.airlinereporter.com/2010/08/opinion-regional-airlines-versus-their-legacy-counterparts/


  5. KevinMam

    August 12, 2021 at 9:01 pm

    dating sites gay men
    gay dating site santa cruz
    [url=”http://gaychatgay.com?”]gay dating planet[/url]


  6. KevinMam

    August 15, 2021 at 6:57 pm

    fw indian gay dating.
    top gay dating site
    [url=”http://gaychatgay.com?”]gay horney sex dating online[/url]


  7. or web hosting

    August 28, 2021 at 4:48 pm

    I could not refrain from commenting. Perfectly written!


  8. t.co

    August 29, 2021 at 7:27 pm

    I feel this is among the so much important information for me.
    And i’m glad studying your article. However want to statement
    on some common things, The site taste is perfect, the articles is truly excellent : D.

    Just right task, cheers


  9. t.co

    August 31, 2021 at 4:01 pm

    I’d like to thank you for the efforts you’ve put in writing this blog.
    I’m hoping to see the same high-grade blog posts from you later
    on as well. In fact, your creative writing abilities has encouraged me to get my own website now 😉


  10. with asmr

    September 1, 2021 at 10:29 am

    I think that is one of the such a lot important information for me.
    And i’m happy studying your article. But want to observation on some general issues, The web site taste is wonderful, the articles is in reality nice :
    D. Excellent task, cheers


  11. scoliosis surgery in

    September 1, 2021 at 6:44 pm

    hello there and thank you for your info –
    I’ve certainly picked up anything new from right here.

    I did however expertise some technical points using this website, as
    I experienced to reload the website a lot of times previous to I could get it to load correctly.
    I had been wondering if your hosting is OK? Not that I’m complaining, but sluggish loading instances times will
    often affect your placement in google and could damage your
    quality score if ads and marketing with Adwords.
    Anyway I am adding this RSS to my email and can look out
    for much more of your respective exciting content.
    Make sure you update this again very soon.


  12. http://j.mp

    September 3, 2021 at 11:57 am

    It’s remarkable in support of me to have a website, which is beneficial in support
    of my know-how. thanks admin


  13. PatrickGloke

    September 3, 2021 at 11:12 pm

    hammond la gay dating don
    one man gay dating site
    [url=”http://gaychatgay.com?”]gay dating targeted individuals[/url]


  14. asmr of

    September 4, 2021 at 11:47 am

    Your style is very unique compared to other people I’ve read
    stuff from. Thanks for posting when you have the opportunity,
    Guess I’ll just bookmark this page.


  15. bitly.com

    September 4, 2021 at 9:05 pm

    Thanks designed for sharing such a nice idea, post is pleasant, thats why i have read it entirely


  16. of scoliosis surgery

    September 5, 2021 at 10:31 pm

    What’s up, constantly i used to check website posts here in the early hours in the morning,
    for the reason that i enjoy to find out more and more.


  17. HenryPic

    September 8, 2021 at 11:40 pm

    gay dating simulation furry
    reddit gay dating in college
    [url=”http://gaydatinglosangeles.com?”]gay pixel art eroge -dating[/url]


  18. tinyurl.com

    September 11, 2021 at 1:18 am

    I’ve been exploring for a bit for any high-quality articles or blog posts on this sort of space .
    Exploring in Yahoo I eventually stumbled upon this website.
    Reading this info So i’m glad to show that I’ve a very excellent uncanny feeling I found out exactly what I needed.
    I such a lot without a doubt will make sure to don?t forget this web site and provides it a look on a relentless basis.
    scoliosis surgery https://0401mm.tumblr.com/ scoliosis surgery


  19. your quest bars

    September 11, 2021 at 7:57 am

    Greetings! This is my first visit to your blog!
    We are a collection of volunteers and starting a new initiative in a community in the same niche.
    Your blog provided us beneficial information to work on. You have done a outstanding job!
    quest bars http://bitly.com/3jZgEA2 quest bars


  20. When someone writes an paragraph he/she maintains the plan of a user in his/her mind that how a user can understand it.

    Thus that’s why this paragraph is outstdanding. Thanks!
    asmr https://app.gumroad.com/asmr2021/p/best-asmr-online asmr


  21. http://tinyurl.com/brah7cp3

    September 13, 2021 at 6:02 am

    You actually make it seem so easy with your presentation but I find this
    topic to be really something which I think I would never understand.
    It seems too complex and very broad for me. I am looking forward for
    your next post, I’ll try to get the hang of it! cheap flights http://1704milesapart.tumblr.com/ cheap flights


  22. www.iherb.com

    September 14, 2021 at 9:51 am

    I’m gone to inform my little brother, that he should also visit this website on regular
    basis to get updated from most up-to-date news update.
    quest bars https://www.iherb.com/search?kw=quest%20bars quest bars


  23. texting rules gay dating

    September 25, 2021 at 4:35 am

    online sites rated gay dating https://gayonlinedating.net/


  24. Brant Cuny

    October 2, 2021 at 9:27 am

    I am interested in more info. How can I contact you? I love sucking dick btw hmu


  25. or ps4 games

    October 25, 2021 at 9:47 am

    I have been surfing on-line greater than three hours lately, yet I never
    discovered any interesting article like yours. It’s lovely value sufficient for me.
    In my opinion, if all web owners and bloggers made good
    content as you did, the web shall be a lot more useful than ever before.


  26. real online casino

    October 27, 2021 at 1:23 am

  27. casino deposit bonus

    October 27, 2021 at 1:52 am

    best online casino reviews https://casinoonlinek.com/


  28. united states online casino

    October 27, 2021 at 10:02 pm

  29. on writing the college application essay

    October 30, 2021 at 3:49 am

    write college essay https://essaytodo.com/


  30. writing a personal essay

    October 30, 2021 at 9:40 am

    argument essay writing https://buy1essay.com/


  31. top write my essay

    October 30, 2021 at 2:11 pm

    writing descriptive essay https://dollaressays.com/


  32. BrandonNub

    November 5, 2021 at 4:24 pm

    formal essay
    [url=”https://dollaressays.com/?”]mla essay example[/url]
    how many paragraphs is an essay


  33. DonaldErumn

    November 10, 2021 at 2:28 am

    parts of an essay
    [url=”https://essaytodo.com/?”]write your essay[/url]
    college essay examples


  34. Hollis Krommes

    November 13, 2021 at 9:32 am

    Custom Printed > covid 19 vaccinated


  35. hospital hentai sex games

    November 24, 2021 at 4:26 pm

    eroge! sex and games make sexy games https://sexgameszone.com/


  36. my sex games

    November 26, 2021 at 11:54 pm

    mom truth or dare sex games https://winsexgames.com/


  37. people playing sex games

    November 27, 2021 at 6:02 pm

  38. Donaldbuigh

    November 29, 2021 at 2:54 pm

    games that have sex
    [url=”https://sex4games.com/?”]kill la kill sex games[/url]
    3d furry sex mmo games


  39. Donaldbuigh

    November 30, 2021 at 11:00 am

    sex games for girls
    [url=”https://sex4games.com/?”]french sex games[/url]
    games of sex


  40. RonaldAnoke

    December 4, 2021 at 6:57 am

    free online sex games for android
    [url=”https://sexgamesx.net/?”]phone sex games[/url]
    japanese sex games


  41. RonaldAnoke

    December 5, 2021 at 8:27 am

    keto brownies recipe
    [url=”https://ketogenicdiets.net/?”]free keto diet plan[/url]
    keto diet cheese


  42. RonaldAnoke

    December 6, 2021 at 6:10 am

    start keto diet
    [url=”https://ketogendiet.net/?”]basic keto diet[/url]
    keto products


  43. sex games on roblox

    December 6, 2021 at 3:02 pm

    sex games porn videos https://cybersexgames.net/


  44. Williamfog

    December 26, 2021 at 11:14 pm

    opinion essay
    [url=”https://checkyouressay.com/?”]writing a conclusion for an essay[/url]
    writing narrative essays


  45. clipsit

    December 28, 2021 at 2:58 am

    Hi there! I just wanted to ask if you ever have any problems with hackers? My last blog (wordpress) was hacked and I ended up losing months of hard work due to no backup. Do you have any solutions to stop hackers?


  46. Henryfer

    December 28, 2021 at 3:42 am

    5 paragraph essay outlin
    [url=”https://essayprepworkshop.com/?”]essay rough draft outline[/url]
    where can i buy an essay


  47. Chrislob

    December 30, 2021 at 3:58 am

    writing an autobiography essay
    [url=”https://dollaressays.com/?”]legit essay writing services[/url]
    define essay


  48. business vpn client r

    January 18, 2022 at 4:06 am

    free vpn torrenting
    [url=”https://addonsvpn.com”]best vpn browser[/url]
    avast secureline vpn


  49. how to write a movie title in an essay j

    January 19, 2022 at 2:18 am

    introduction essay
    [url=”https://anenglishessay.com”]how to start college essay[/url]
    college narrative essay


  50. chat-avenue/gay j

    January 20, 2022 at 12:22 am

    naked gay chat rooms
    [url=”https://bjsgaychatroom.info”]gay live chat rochester video[/url]
    random gay chat cams


  51. avast vpn download t

    January 20, 2022 at 11:57 pm

    ivacy vpn
    [url=”https://choosevpn.net”]best vpn netflix[/url]
    vpn for kodi


  52. critical thinking and analysis w

    January 21, 2022 at 9:56 pm

    what is an example of critical thinking
    [url=”https://criticalthinking2020.net”]critical thinking in schools[/url]
    critical thinking vs analytical thinking


  53. critical thinking tools k

    January 22, 2022 at 8:10 pm

    critical thinking and perception
    [url=”https://criticalthinkingbasics.com”]critical thinking in the classroom[/url]
    interview questions critical thinking


  54. critical thinking ted talk m

    January 23, 2022 at 6:06 pm

    how to learn critical thinking
    [url=”https://criticalthinkinginstitute.com”]critical thinking riddles[/url]
    barriers of critical thinking


  55. essay steps u

    January 24, 2022 at 4:22 pm

    500 word essay length
    [url=”https://essayscratch.com”]the college essay guy[/url]
    what is an informative essay


  56. persuasive essay topics g

    January 25, 2022 at 2:48 pm

    how to start an informative essay
    [url=”https://essaysitesreviews.com”]an argumentative essay[/url]
    interesting argumentative essay topics


  57. indian gay chat room e

    January 26, 2022 at 1:06 pm

    free gay video chat room
    [url=”https://gay-buddies.com”]free gay chat apps for windows[/url]
    where to chat with gay pervs


  58. gay chub dating k

    January 27, 2022 at 8:03 am

    gay teen dating an older partner
    [url=”https://gayfade.com/”]browse gay dating ads[/url]
    indianapolis gay dating


  59. gay man, straight man dating p

    January 28, 2022 at 12:46 am

    gay military dating scam
    [url=”https://gaypridee.com/”]gay dating apps 2019[/url]
    gay dating apps for pc


  60. free dating gay sites s

    January 28, 2022 at 5:08 pm

    gay tips for gay bottom dating
    [url=”https://gayprideusa.com/”]adam for adam gay online dating[/url]
    squirt gay hook up dating cruising and sex site


  61. about dating gay spanish men n

    January 29, 2022 at 8:55 am

    black gay dating
    [url=”https://gaysugardaddydatingsites.com/”]gay dating apps described[/url]
    gay dating upstate new youk


  62. gay chat room in nj j

    January 30, 2022 at 5:45 am

    chatavenue gay chat
    [url=”https://gaytgpost.com/”]free chat on gay webcam[/url]
    gay men chat cam


  63. keto diet definition q

    February 1, 2022 at 12:16 am

    beer on keto diet
    [url=”https://ketogendiet.net/”]keto diet testosterone[/url]
    keto diet meal


  64. keto diet diabetes d

    February 1, 2022 at 10:03 pm

    bcaa on keto diet
    [url=”https://ketogendiets.com/”]keto diet for cancer[/url]
    after keto diet


  65. ซุปเปอร์สล็อต

    March 8, 2022 at 6:56 pm

    Thanks again for the blog post.Really looking forward to read more. Really Great.


Leave a Reply

Your email address will not be published. Required fields are marked *

Check Also

Did Nets’ Kevin Durant Undergo Crazy Body Transformation? (Photos) – Game 7 – Game7

[ad_1] Brooklyn Nets star Kevin Durant is already arguably the best player in the NBA. Alt…