Home Health News South African Covid variant may affect vaccine efficacy, warn scientists – Financial Times

South African Covid variant may affect vaccine efficacy, warn scientists – Financial Times

8 min read

The new coronavirus variant linked to a surge in Covid-19 cases in South Africa is not only more infectious than previous forms of the virus but could make some vaccines less effective.

Scientists racing to understand the new strain said they still expected the current crop of approved vaccines to work but were worried that a specific mutation, also identified in a new variant in Brazil, could affect the way the virus responds.

“At this moment, we think that a vaccine could be a little less effective,” Professor Tulio de Oliveira, of the University of KwaZulu-Natal, who is leading South Africa’s scientific effort to understand the 501Y.V2 strain, told the Financial Times. “[But] between all the varieties of vaccines that are coming to the market, we still have strong belief that some of them will be very effective.”

The mutation in question, called E484K, changes the “receptor binding domain” — a key part of the spike protein that the virus uses to enter human cells. This is also an important site at which neutralising antibodies induced by infection or vaccination bind to the virus.

A team at the Fred Hutchinson Cancer Research Center in Seattle has assessed the ability of antibodies taken from people previously infected with Sars-Cov-2 to neutralise various new strains of coronavirus.

Their study, released on Tuesday but not peer-reviewed, found that “emerging lineages in South Africa and Brazil carrying the E484K mutation will have greatly reduced susceptibility to neutralisation by the . . . serum antibodies of some individuals”. However, the effect was much stronger in some people than others, the paper said.

Prof de Oliveira’s team in South Africa have reached similar conclusions. “This finding about antibody neutralisation was highlighted very strongly in our paper,” he said. “There is a reason to be concerned.”

Prof de Oliveira added that his team had spent “the last 15 days, working day and night, with the top laboratories in South Africa” and would release “strong preliminary results” soon.

The 501Y.V2 variant emerged in August in South Africa’s Nelson Mandela Bay in the Eastern Cape, before spreading to other provinces as the country’s second wave of Covid-19 infections accelerated in recent weeks. Out of South Africa’s 1.1m total confirmed cases to date, about 100,000 have been in the past seven days.

Coronavirus variants are emerging around the world as Sars-Cov-2 passes between tens of millions of people. On average, the virus accumulates about two mutations per month but it can change more quickly under some circumstances — for example within an individual who has a suppressed immune system and remains infected for many weeks.

The South African and Brazilian strains share several mutations with the fast-spreading B.1.1.7 variant in the UK, which made its first known appearance in Kent in late September. But B.1.1.7 does not have the E484K mutation.

For this reason, “most scientists with a view on these variants are more concerned about the South African one than the Kent one,” said Francois Balloux, director of the University College London Genetics Institute.

Matt Hancock, the UK health secretary, has expressed concern about the South African variant on several occasions saying on Monday that he was “incredibly worried”.

Prof de Oliveira described Mr Hancock’s comments, which were perceived by some in South Africa as an attempt to deflect attention from the UK, as “very unfortunate”.

“We are really trying our best to see if that politicisation can decrease,” he said. “We are working very closely with British scientists. We have been exchanging data and knowledge on an almost daily basis on the scientific front. Our job as the global scientific community is to try and de-escalate that kind of tension.”

The UK and South Africa — unlike most other countries — have conducted extensive genomic sequencing throughout the pandemic, enabling health officials to track mutations quickly. This could mean that other more infectious variants are already spreading in other countries undetected.

So far, no new Sars-Cov-2 variant is known to cause more severe disease than the original virus that emerged in China at the end of 2019, but more rapid rates of transmission have piled greater pressure on hospitals and health systems.

“The main take-home message is that we should not be playing with this virus by letting it transmit for so long,” said Prof de Oliveira. “More than ever, this is a global problem and we should be looking for a global coalition to respond.”

Let’s block ads! (Why?)

Source link


  1. Billie Garrigan

    January 12, 2021 at 3:49 am

    Hiya, I’m really glad I have found this information. Nowadays bloggers publish just about gossips and web and this is really annoying. A good site with interesting content, that is what I need. Thanks for keeping this web site, I’ll be visiting it. Do you do newsletters? Can’t find it.


  2. cannabis

    February 12, 2021 at 3:36 am

    If men could see the epitaphs their friends write they would believe they had gotten into the wrong grave.


  3. asmr https://0mniartist.tumblr.com

    April 10, 2021 at 11:54 pm

    A motivating discussion is definitely worth comment.
    I believe that you ought to write more on this subject, it may not be a taboo subject but usually
    folks don’t discuss such issues. To the next! Many thanks!!

    0mniartist asmr


  4. 0mniartist

    April 11, 2021 at 11:53 pm

    I have been surfing online more than 4 hours
    today, yet I never found any interesting article
    like yours. It is pretty worth enough for me. In my opinion, if all webmasters and bloggers made good content
    as you did, the web will be much more useful than ever before.
    0mniartist asmr


  5. asmr https://0mniartist.tumblr.com

    April 13, 2021 at 8:48 am

    I visit each day some blogs and sites to read articles
    or reviews, except this blog gives quality based content.
    0mniartist asmr


  6. http://bit.ly/3mPeyCz

    April 14, 2021 at 6:55 pm

    Hello! I know this is kinda off topic but I was wondering which blog platform are you using for this site?

    I’m getting sick and tired of WordPress because I’ve had issues with hackers and I’m looking at
    alternatives for another platform. I would be great if
    you could point me in the direction of a good platform.
    0mniartist asmr


  7. bit.ly

    April 16, 2021 at 3:04 am

    I’ve read some just right stuff here. Certainly
    worth bookmarking for revisiting. I wonder how so much effort you set to create the sort of wonderful informative
    web site. asmr 0mniartist


  8. Bess

    April 20, 2021 at 5:35 pm

    Money is the root of all evil.


  9. austin pool removal

    April 24, 2021 at 12:48 am

    Put a stout heart to a stey brae.


  10. gamefly on

    April 28, 2021 at 3:55 am

    Have you ever thought about publishing an e-book or guest authoring on other websites?
    I have a blog based upon on the same information you discuss and would really like
    to have you share some stories/information. I know my viewers
    would enjoy your work. If you’re even remotely interested,
    feel free to send me an email.


  11. that asmr

    April 29, 2021 at 7:01 am

    We stumbled over here from a different web address and thought I should
    check things out. I like what I see so i am just following you.
    Look forward to looking over your web page repeatedly.


  12. asmr an

    April 29, 2021 at 7:56 am

    I was curious if you ever thought of changing the page layout
    of your blog? Its very well written; I love what youve got to
    say. But maybe you could a little more in the way of content so people could connect with
    it better. Youve got an awful lot of text for only having 1 or 2
    pictures. Maybe you could space it out better?


  13. asmr is

    April 29, 2021 at 4:06 pm

    Hey I am so excited I found your blog page, I really found you by accident, while I was looking on Yahoo for something else, Anyways I am here now and would
    just like to say kudos for a incredible post and a all
    round entertaining blog (I also love the theme/design),
    I don’t have time to go through it all at the minute but I have
    bookmarked it and also added in your RSS feeds, so when I
    have time I will be back to read a lot more, Please do keep up the awesome work.


  14. gamefly their

    May 3, 2021 at 11:44 pm

    Hey there! Do you know if they make any plugins to help
    with SEO? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good gains.
    If you know of any please share. Cheers!


  15. is asmr

    May 4, 2021 at 10:39 am

    It’s actually very complicated in this active
    life to listen news on Television, so I simply use the web for that reason, and obtain the latest news.


  16. j.mp

    May 7, 2021 at 9:54 am

    I don’t even understand how I stopped up right here,
    but I assumed this post used to be great. I do not realize who you’re
    but definitely you are going to a famous blogger in case you are not already.


  17. is asmr

    May 8, 2021 at 3:39 am

    This post is actually a pleasant one it assists new internet
    viewers, who are wishing in favor of blogging.


  18. our asmr

    May 9, 2021 at 4:41 pm

    Hi there colleagues, how is the whole thing, and what you
    want to say about this article, in my view its actually remarkable designed for me.


  19. Johnsie Ramoutar

    May 11, 2021 at 10:51 am

    Have you ever heard of second life (sl for short). It is basically a game where you can do anything you want. SL is literally my second life (pun intended lol). If you would like to see more you can see these second life articles and blogs


  20. http://bitly.com/3hsQ2qo

    May 15, 2021 at 8:12 am

    Hi to all, how is the whole thing, I think every
    one is getting more from this website, and your views are good in favor
    of new users. scoliosis


  21. dumpster rental near me

    May 15, 2021 at 10:45 pm

    Practice makes perfect.


  22. bitly.com

    May 16, 2021 at 3:06 pm

    Hi, i think that i saw you visited my blog so i came to go
    back the choose?.I am attempting to in finding things to improve my website!I assume its adequate to use a few of your concepts!!


  23. http://bitly.com

    May 19, 2021 at 10:28 am

    An outstanding share! I have just forwarded this onto a coworker who had been doing a little homework on this.
    And he actually ordered me lunch simply because I found it for him…
    lol. So let me reword this…. Thanks for the meal!!

    But yeah, thanks for spending some time to talk about this issue here on your blog.


  24. https://785days.tumblr.com/

    May 20, 2021 at 4:39 am

    free dating sites
    I think this is among the most important info for me.
    And i’m glad reading your article. But wanna remark on few general things,
    The web site style is great, the articles is really great :
    D. Good job, cheers https://785days.tumblr.com/ free dating sites


  25. https://6869milesoflove.tumblr.com/

    May 20, 2021 at 10:48 am

    free dating sites
    Heya this is kind of of off topic but I was wondering if blogs use
    WYSIWYG editors or if you have to manually code with HTML.
    I’m starting a blog soon but have no coding know-how so I
    wanted to get guidance from someone with experience.
    Any help would be greatly appreciated! dating sites


  26. in asmr

    May 21, 2021 at 8:27 am

    Keep on writing, great job!


  27. tổ chức workshop

    May 22, 2021 at 2:24 pm

    There is perceptibly a lot to identify about this. I consider you made various nice points in features also.


  28. free dating sites that

    May 26, 2021 at 4:39 am

    Having read this I believed it was extremely enlightening.
    I appreciate you finding the time and effort to put this informative article together.
    I once again find myself spending way too much time both
    reading and posting comments. But so what, it was still worth it!


  29. where free dating sites

    May 26, 2021 at 8:23 am

    With havin so much content and articles do you ever run into any issues of plagorism or copyright infringement?
    My website has a lot of exclusive content I’ve either written myself or outsourced but it seems a lot of it is popping it up all over the web without
    my authorization. Do you know any techniques to help stop content from being
    ripped off? I’d truly appreciate it.


  30. dating sites our

    May 29, 2021 at 7:38 am

    Magnificent web site. A lot of helpful information here.
    I’m sending it to some buddies ans additionally sharing in delicious.
    And of course, thanks to your effort!


  31. an surgery scoliosis

    May 30, 2021 at 8:51 pm

    Thanks for the auspicious writeup. It actually was once a amusement account it.
    Look complex to far brought agreeable from you!

    However, how could we be in contact?


  32. scoliosis where

    May 31, 2021 at 2:44 am

    Awesome! Its truly remarkable paragraph, I have got much clear idea about from this article.


  33. free dating sites the

    May 31, 2021 at 2:58 pm

    My brother recommended I might like this web site.
    He was entirely right. This post truly made my day.

    You can not imagine just how much time I had spent
    for this information! Thanks!


  34. with dating sites

    May 31, 2021 at 11:29 pm

    Its like you read my mind! You seem to know a lot about this,
    like you wrote the book in it or something. I think that you could do with some pics to drive the message home a bit, but other than that,
    this is great blog. An excellent read. I’ll certainly be back.


  35. tinyurl.com

    June 1, 2021 at 3:39 pm

    You could definitely see your enthusiasm in the work you write.
    The sector hopes for more passionate writers like you who aren’t afraid to
    mention how they believe. At all times go after your heart.


  36. http://tinyurl.com

    June 2, 2021 at 3:15 am

    Nice post. I used to be checking continuously this weblog and I’m impressed!

    Very useful info specifically the last phase 🙂 I handle such info much.
    I was seeking this particular info for a long time. Thanks
    and best of luck.


  37. Williamdup

    July 27, 2021 at 9:20 pm

    free dating near you
    [url=”http://onlinedatingtwo.com/?”]malia obama dating[/url]


Leave a Reply

Your email address will not be published. Required fields are marked *

Check Also

Want to Lose Weight? Include These 5 Dry Fruits in Your Diet – India.com

Weight Loss Tips: Want to Lose Weight? Include These 5 Dry Fruits in Your Diet <!–…